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Protein-coding gene in the species Homo sapiens
Giantin or Golgin subfamily B member 1 is a protein that in humans is encoded by the GOLGB1 gene .[ 5] [ 6] [ 7] Golgi apparatus and is part of the Golgi matrix that is responsible for membrane trafficking in secretory pathway of proteins. This function is key for proper localisation of proteins at the plasma membrane and outside the cell (extracellular region) which is important for cell function that is dependent on for example receptors and the extracellular matrix function. Recent animal model knockout studies of GOLGB1 in mice ,[ 8] rat ,[ 9] zebrafish [ 10] tumoral calcinosis -like phenotype was observed, and in humans such phenotype has been linked to defective glycosyltransferase function (e.g. GALNT3 protein).[ 11]
Function and Interactions [ edit ] Giantin is a disulfide-linked homodimer which contains several (around 37) coiled-coiled domains. GOLGB1 protein has been shown to interact with ACBD3 and with PLK3 [ 12] [ 13] GM130 [ 14] primary cilia [ 15] [ 16] glycosyltransferase expression and calcineurin signalling in tissue culture cells.[ 17] [ 18]
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