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Protein-coding gene in the species Homo sapiens
NWD1 , short for NACHT and WD repeat domain containing 1, is a gene found in vertebrates , which encodes a protein that contains a NACHT domain and a WD40 repeat domain. It was originally identified during a search for immune system genes in zebrafish as a protein coding sequence related to APAF1 ; orthologs were subsequently identified in mammalian species .[ 5] NWD1 gene of humans is located on chromosome 19 . Current data suggests a causal role for tumor-associated over-expression of NWD1 in the dysregulation of androgen receptor signaling during prostate cancer progression.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000188039 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048148 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Stein C, Caccamo M, Laird G, Leptin M (2007). "Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish" . Genome Biol . 8 (11): R251. doi :10.1186/gb-2007-8-11-r251 PMC 2258186 PMID 18039395 . ^ Correa RG, Krajewska M, Ware CF, Gerlic M, Reed JC (2014). "The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling" . Oncotarget . 5 (6): 1657–1665. doi :10.18632/oncotarget.1850 . PMC 4039239 PMID 24681825 .
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